Alignment of several interesting Fz family members made by RN using the ClustalW program on DeCypher (July 15, 1999)
fz3/mouse --------------------MAVSWIVFDLWLLTVFLG---QIGGHS--------LFSCE
fz4/mouse ------MAWPGTGPS---SRGAPGGVGLRLGLLLQFLLLLRPTLGFGD-----EEERRCD
fz8/mouse ---------MEWGYL-----LEVTSLLAALAVLQRSSG-AAAASAK---------ELACQ
fz5/human ---------MARPDP-----SAPPSLL--LLLLAQLVG-RAAAASK---------APVCQ
fzd9/human -----MAVAPLRGALLLWQLLAAGGAALEIGRFD-------PERGRG--------AAPCQ
fz1/rat LEAPLLLGVRAQPAG---QVSG-PGQQRPPPPQPQQGG--QQYNGERG--ISIPDHGYCQ
fz2/rat --------MRARSAL---PRSALPRLLLPLLLLPAAGP--AQFHGEKG--ISIPDHGFCQ
fz/Dros ILPTLIQGVQRYDQS---PLDASPYYRSGGGLMASSG---TELDG-------LPHHNRCE
fz2/Dros/ GLVLLLTSCRADGPL-----HSADHGMGGMGMGGHGLD-ASPAPGYGVPAIPKDPNLRCE
. *:
________________________CRD_________________________________
fz3/mouse PITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPIC
fz4/mouse PIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMC
fz8/mouse EITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPIC
fz5/human EITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCTMYTPIC
fzd9/human AVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMC
fz1/rat PISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVC
fz2/rat PISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC
fz/Dros PITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVC
fz2/Dros/ EITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC
: : * .: ** :** .* * * : : *::: * : :**: *:*
________________CRD_________________
fz3/mouse M-EYGRVTLPCRRLCQRAYSECSKLMEMFG-VPWPEDMECSRFPDCD-EPYPRLVDLN--
fz4/mouse TEKINIPIGPCGGMCLSVKRRCEPVLREFG-FAWPDTLNCSKFPPQN-DHNHMCMEGP--
fz8/mouse LEDYKKPLPPCRSVCERAKAGCAPLMRQYG-FAWPDRMRCDRLPEQG-NPDTLCMDYN-R
fz5/human LPDYHKPLPPCRSVCERAKAGCSPLMRQYG-FAWPERMSCDRLPVLGRDAEVLCMDYN-R
fzd9/human TDQVSTPIPACRPMCEQARLRCAPIMEQFN-FGWPDSLDCARLPTRN-DPHALCMEAPEN
fz1/rat T-VLEQALPPCRSLCERA-QGCEALMNKFG-FQWPDTLKCEKFPVHG--AGELCVGQNTS
fz2/rat T-VLEQAIPPCRSICERARQGCEALMNKFG-FQWPERLRCEHFPRHG--AEQICVGQNHS
fz/Dros T-ILERPIPPCRSLCESA-RVCEKLMKTYN-FNWPENLECSKFPVHG--GEDLCVAENTT
fz2/Dros/ LEDYHKPLPVCRSVCERARSGCAPIMQQYS-FEWPERMACEHLPLHG-DPDNLCMEQPSY
* :* . * **. : * :* :
fz3/mouse --------------------------------------------------LVGDPTE---
fz4/mouse ---GDEE--------------------------------------------VPLPHKTP-
fz8/mouse TDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGG
fz5/human SEATTAPPRP---FPAKP---TLP--G-----PP--------------G----APAS-GG
fzd9/human ATAGPAEPHK----GLGM----LP--------------------------VAPRPARPPG
fz1/rat DKGTPTPSL-------------L--------------------------PEFWTSNPQHG
fz2/rat EDG--TPAL-------------L--------------------------TTAPPSGLQPG
fz/Dros SSA----------------------------------------------STAATPTRSVA
fz2/Dros/ TEAGSGGSSG----GSGG---SGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCR-GR
.
_________TM1____________
fz3/mouse YSFLHVRDCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTR
fz4/mouse --LNCVLKCGYDAG--------LYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSR
fz8/mouse -KTGQIANCALPCHN------PFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMER
fz5/human -RTGQVPNCAVPCYQ------PSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMDT
fzd9/human --RSCAPRCGPGVEV-------FWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHR
fz1/rat LGEK---DCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRR
fz2/rat LGER---DCAAPCEPARPDGSMFFSHHHTRFARLWILTWSVLCCASTFFTVTTSLVAMQR
fz/Dros VGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSR
fz2/Dros/ QRIAGVPNCGIPCKG------PFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTER
* : : :* :. *
____________TM2______
fz3/mouse FRYPERPIIFYAVCYMMVSLIFFIGFLLE-DRVACNASSP--------------------
fz4/mouse FSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF-----------------------
fz8/mouse FKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGRGGAGGAAAAGAGAAG
fz5/human FRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACS------------------------
fzd9/human FQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACD------------------------
fz1/rat FSYPERPIIFLSGCYTAVAVAYIAGFLLE-DRVVCNDKFAE-------------------
fz2/rat FRYPERPIIFLSGCYTMVSVAYIAGFVLQ-ERVVCNERFSE-------------------
fz/Dros FRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVK---LG-----------
fz2/Dros/ FKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDG-----------------------
* ****.::* . ** . :.
____________TM3_________
fz3/mouse --------------AQYKASTVTQGSHNK-ACTMLFMVLYFFTMAGSVWWVILTITWFLA
fz4/mouse --------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLA
fz8/mouse RGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLA
fz5/human R----------------EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLA
fzd9/human --------------QEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLA
fz1/rat ----------------DGARTVAQGTKKE-GCTILFMMLYFFSMASSIWWVILSLTWFLA
fz2/rat ----------------DGYRTVGQGTKKE-GCTILFMMLYFFSMASSIWWVILSLTWFLA
fz/Dros --------------RLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLA
fz2/Dros/ -------------------LLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILTFTWFLA
: * :: : :.. ** ::: ::*:
____________TM4____
fz3/mouse AVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYF
fz4/mouse AGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGF
fz8/mouse AGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGF
fz5/human AAMKWGNEAIAGYGQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRRF
fzd9/human AGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGF
fz1/rat AGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGF
fz2/rat AGMKWGHAAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNRLDPLRGF
fz/Dros AGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAF
fz2/Dros/ AGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTF
: **. *: . ** ** * .: * : : . : *:*:. *
______________TM5______ _______
fz3/mouse VLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKE-----NQDKLVKFMIRIGVFSILYL
fz4/mouse VVAPLFTYLVIGTLFIAAGLVALFKIRSNLQK-DG----TKTDKLERLMVKIGVFSVLYT
fz8/mouse VLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGP---TKTHKLEKLMIRLGLFTVLYT
fz5/human VLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ-GG----TKTDKLEKLMIRIGIFTLLYT
fzd9/human VLVPLSGYLVLGSSFLLTGFVALFHIRKIMKT-GG----TNTEKLEKLMVKIGVFSILYT
fz1/rat VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH-DG----TKTEKLEKLMVRIGVFSVLYT
fz2/rat VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH-DG----TKTEPLERLMVRIGVFSVLYT
fz/Dros LILPLCIYLSIGALFLLAGFISLFRIRTVMKT-DG----KRTDKLERLMLRIGFFSGLFI
fz2/Dros/ VLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYT
: * : :* : . :* :: : . : :: :: .*: *:
___TM6______ ________
fz3/mouse VPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMS-------RPDLILFLM
fz4/mouse VPATCVIACYFYEISNWALFRYSADDS--------------------------NMAVEML
fz8/mouse VPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARR-------------PDYAVFML
fz5/human VPASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAK-------------PEYWVLML
fzd9/human VPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLP----GGSVPTVAVFML
fz1/rat VPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMI
fz2/rat VPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYT-------PRTSPDFTVYMI
fz/Dros LPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGS----PEARPIFQIFMV
fz2/Dros/ VPATIVIGCYLYEAAYFEDWIKALACPCAQVK--GPGKK-------------PLYSVLML
* : . . * ::
_______TM7______
fz3/mouse KYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNT
fz4/mouse KIFMSLLVGITSGMWIWSAKTLHTWQKCS-----------NRLVNSGKVK-----REKRG
fz8/mouse KYFMCLVVGITSGVWVWSGKTLESWRALC-----------TRCCWASKGAAVGAGAGGSG
fz5/human KYFMCLVVGITSGVWIWSGKTVESWRRFT-----------SRCCCRPR-------RGHK-
fzd9/human KIFMSLVVGITSGVWVWSSKTFQTWQSLC-----------YRKIAAGRARA----KACRA
fz1/rat KYLMTLIVGITSGFWIWSGKTLNSWRKFY-----------TRLTNSK--------QGETT
fz2/rat KYLMTLIVGITSGFWIWSGKTLHSWRKFY-----------TRLTNSR--------HGETT
fz/Dros KYLCSMLVGVTSSVWLYSSKTMVSWRNFV-----------ERLQGKEPRT-----RAQAY
fz2/Dros/ KYFMALAVGITSGVWIWSGKTLESWRRFW-----------RRLLGAPDRTGANQALIKQR
: : : * : .*: * ** :